Liverpool manager Juergen Klopp has a midfield conundrum and his Tottenham counterpart Mauricio Pochettino must decide whether Harry Kane is ready for action as both bosses face selection dilemmas for Saturday's Champions League final.
Bukayo Saka scored either side of halftime as Arsenal crushed second-bottom Burnley 5-0.
Eddie Howe's side were ruthless in boosting their Champions League qualification hopes while 19th-placed Leicester became the first side in English Football League history to suffer eight successive home league defeats without scoring.
Mohamed Salah is keen to make a decisive contribution in Saturday's Champions League final against Tottenham Hotspur and help lay to rest the demons of Liverpool's nightmare defeat by Real Madrid a year ago.
The 58-year-old pointed to the 26-point gap in the Premier League table between runners-up Liverpool and his fourth-placed former team as evidence of a massive gulf between the sides.
Inter Milan face Barcelona, Tottenham Hotspur and PSV Eindhoven in Group B which features three former European champions.
Third-placed Aston Villa are the surprise package of the season and Unai Emery's side face relegation-threatened Burnley while fifth-placed Spurs host a resurgent Bournemouth who have 19 points from their last seven games.
Liverpool goalkeeper Simon Mignolet saved an early penalty and James Milner's shot was deflected into his own net by Havard Nordtveit for the English Premier League side's second goal in an end-to-end match.
Five-times European champions Liverpool slumped to a 2-1 defeat against Besiktas on Wednesday and now face an uphill task to progress from Champions League Group A.
Manchester City struck an early blow for the forthcoming Premier League campaign as they beat Liverpool on penalties to win the Community Shield at Wembley on Sunday after an absorbing contest had finished 1-1.
The English side drew goalless with Juventus in the second leg, but made it to the Champions League semi-finals with a 2-1 aggregate.
Barcelona have been haunted by their recent failures in the Champions League and there are concerning signs for the Catalans as they prepare for Tuesday's last-16 first leg away to Olympique Lyonnais.
Jarrod Bowen and Mohammed Kudus' second-half goals gave West Ham a 2-0 win over Manchester United in the Premier League's early game on Saturday, as the Hammers briefly moved into the top six.
Substitute Gabriel Martinelli fired a last-gasp winner to earn Arsenal a 1-0 victory over Manchester City on Sunday.
Leipzig will likely need to find an alternate venue or shift the two-leg tie around and first play in England.
Arsenal, who trail Premier League leaders Liverpool by 12 points with nine games remaining, host Real Madrid in the first leg of their Champions League quarter-final next week.
The 2024-25 Champions League is the first to be run under the "Swiss system", in which each team play eight matches in a group phase that will not finish until late January.
Liverpool boss Juergen Klopp has said his team will be 'on fire' for the Champions League final
A double from Vinicius laid the foundation for a thumping Champions League win.
Man City to face Spurs in League Cup
Teenager Curtis Jones grabbed a 58th-minute winner as an injury-hit Liverpool qualified for the knockout stage of the Champions League with a 1-0 win over Ajax Amsterdam at Anfield on Tuesday.
The LFC Supporters Board called the price increase "cruel, unjust, unreasonable and unfair" amid a cost-of-living crisis in Britain, where annual inflation remains above 10%.
"The result of the first leg, in this aspect, puts us a little in doubt. We will try to go all in out there from the first minute, but we have more questions and responsibility than our rival."
Runaway Premier League leaders Manchester City will play Borussia Dortmund with the winners to face either Bayern or PSG in the semi-finals.
AC Milan will have to be perfect defensively when they host Premier League side Liverpool in their Champions League opener at San Siro, manager Paulo Fonseca said on Monday.
With a game in hand, Hansi Flick's Barca are top on 66 points, three ahead Real in second
Manchester City manager Pep Guardiola has noticed an increase in opposing teams adopting a man-marking approach.
A summary of Wednesday's Champions League first leg quarter-finals between Barcelona and Dortmund and Real Madrid, and Paris St Germain and Aston Villa.
Arsenal defeated London rivals Chelsea 1-0 for their first win in four Premier League games on Sunday as a headed goal by stand-in striker Mikel Merino boosted their faint hopes of catching up with runaway leaders Liverpool.
Liverpool forward Sadio Mane has dispatched 300 club jerseys to supporters in his home village of Bambali in Senegal ahead of Saturday's Champions League final against Real Madrid.
Manchester United climb into sixth place with 3-0 West Ham win
After the Champions League game, Liverpool host Arsenal in the league on Sunday.
Athletic Bilbao beat Barcelona 4-2 at home to knock them out of the Copa del Rey
Modest Braga, who have never won a Portuguese league title, stunned five-times European champions Liverpool 1-0 with a first-half penalty in the Europa League on Thursday.
Liverpool scored three goals in 12 dramatic first-half minutes, two of them from Emre Can, on their way to a hugely entertaining 4-2 win over Hoffenheim which took them back to the Champions League group stage after a two-season absence on Wednesday.
Arsenal moved to 50 points from 24 games.
Holders Real Madrid breezed into the last 16 of the Champions League with two games to spare when a Karim Benzema strike secured a 1-0 win in their Group B match at home to a toothless Liverpool on Tuesday.
Xabi Alonso scored twice as the European champions rallied from 1-3 down to win 5-3.
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